sex chromosomal aberration report of the percentage and different karyotypes of sex chromosomal aberration among 163444 cytogenetic tests.

The Role of Chromosomal Aberration in Childhood Leukemia

Radiosensitizing effects of melatonin on radiation induced chromosomal aberration in G2-lymphocytes of breast cancer patients

Background: Radiotherapy is regarded as a standard treatment modality in breast cancer (BC). Radiation causes cellular damage both in cancer and normal cells by inducing DNA-damage and chromosomal aberrations (CA). Different agents were used for ameliorating effects of radiation, mainly antioxidants such as melatonin. Melatonin shows oncostatic properties on human BC. The aim of this study was ...

Lymphocyte chromosomal aberration assay in radiation biodosimetry

Exposure to ionizing radiations, whether medical, occupational or accidental, leads to deleterious biological consequences like mortality or carcinogenesis. It is considered that no dose of ionizing radiation exposure is safe. However, once the accurate absorbed dose is estimated, one can be given appropriate medical care and the severe consequences can be minimized. Though several accurate phy...

the role of chromosomal aberration in childhood leukemia

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Application of conventional chromosomal aberration and fluorescence in situ hybridisation (FISH) translocation in the assessment of occupationally derived irradiation

Background: Most of our current understanding of the biological effects of exposure to ionising radiation is based on conventional cytogenetic techniques, which enable us to determine the relationship between chromosomal aberration and dose received by radiation workers. However, conventional techniques have numerous limitations and chromosomal aberrations can be easily missed. Since FISH plays...

Determination of Chromosomal Sex ‡

The sex of an individual may be defined in three different ways: a. The type of gonad present b. General anatomical appearance and psychological orientation c. Genetic factors as determined by the presence of the XX or XY chromosomes. If uniformity is absent or equivocal in these characteristics, the decision as to whether an individual should be classified as male or female is difficult and is...